没落
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To be ruined, bankrupt, downfallen. But usually ruined, or washed-up.
NP
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滅亡
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The downfall of a civilization or the dying-out of a certain ethnic group.
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崩壊
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To collapse – said of a building, but also (figuratively) like ‘The collapse of communism.’
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破壊
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Destruction. This usually means physical destruction, but if you’re looking for a word with the ‘this will be your downfall!’ blame-a-dude aspect, 破壊 works better than the previous two.
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絶滅
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(for animals) To go extinct.
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Neither 滅亡 nor 崩壊 have the moral ‘It’s your own fault’ judgment of the English word ‘downfall.’