休み | Could be anything from a short break to summer vacation – it all depends on the word before it. $$$ |
休憩 | Break at work (昼休み is actually a type of きゅうけい) OR break from studying/training. Just long enough to eat some food and stretch – usually 15 minutes to an hour. |
休日 | A holiday – Christmas, Arbor Day, etc. |
休暇 | Long vacation from work (maternity leave, 2-week vacation to Barbados, etc.) |